Keratin 17 is a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma.

ABSTRACT:

Objectives

To determine the role of keratin 17 (K17) as a predictive biomarker for response to chemotherapy by defining thresholds of K17 expression based on immunohistochemical tests that could be used to optimize therapeutic intervention for patients with pancreatic ductal adenocarcinoma (PDAC).

Methods

We profiled K17 expression, a hallmark of the basal molecular subtype of PDAC, by immunohistochemistry in 2 cohorts of formalin-fixed, paraffin-embedded PDACs (n = 305). We determined a K17 threshold of expression to optimize prognostic stratification according to the lowest Akaike information criterion and explored the potential relationship between K17 and chemoresistance by multivariate predictive analyses.

Results

Patients with advanced-stage, low K17 PDACs treat

SUBMITTER: Delgado-Coka LA 

PROVIDER: S-EPMC11369068 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature