Cognitive subgroups of affective and non-affective psychosis show differences in medication and cortico-subcortical brain networks.

ABSTRACT: Cognitive deficits are prevalent in individuals with psychosis and are associated with neurobiological changes, potentially serving as an endophenotype for psychosis. Using the HCP-Early-Psychosis-dataset (n = 226), we aimed to investigate cognitive subtypes (deficit/intermediate/spared) through data-driven clustering in affective (AP) and non-affective psychosis patients (NAP) and controls (HC). We explored differences between three clusters in symptoms, cognition, medication, and grey matter volume. Applying principal component analysis, we selected features for clustering. Features that explained most variance were scores for intelligence, verbal recognition and comprehension, auditory attention, working memory, reasoning and executive functioning. Fuzzy K-Means clustering on those feat

SUBMITTER: Bracher KM 

PROVIDER: S-EPMC11369100 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature