Nitroglycerin challenge identifies microcirculatory target for improved resuscitation in patients with circulatory shock.

ABSTRACT:

Background

Circulatory shock and multi-organ failure remain major contributors to morbidity and mortality in critically ill patients and are associated with insufficient oxygen availability in the tissue. Intrinsic mechanisms to improve tissue perfusion, such as up-regulation of functional capillary density (FCD) and red blood cell velocity (RBCv), have been identified as maneuvers to improve oxygen extraction by the tissues; however, their role in circulatory shock and potential use as resuscitation targets remains unknown. To fill this gap, we examined the baseline and maximum recruitable FCD and RBCv in response to a topical nitroglycerin stimulus (FCD_NG, RBCv_NG) in patients with and without circulatory shock to test whether this may be a method to identify

SUBMITTER: Bertacchi M 

PROVIDER: S-EPMC11369126 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature