Differential Responses to Aging Among the Transcriptome and Proteome of Mesenchymal Progenitor Populations.

ABSTRACT: The biological aging of stem cells (exhaustion) is proposed to contribute to the development of a variety of age-related conditions. Despite this, little is understood about the specific mechanisms which drive this process. In this study, we assess the transcriptomic and proteomic changes in 3 different populations of mesenchymal progenitor cells from older (50-70 years) and younger (20-40 years) individuals to uncover potential mechanisms driving stem cell exhaustion in mesenchymal tissues. To do this, we harvested primary bone marrow mesenchymal stem and progenitor cells (MPCs), circulating osteoprogenitors (COP), and adipose-derived stem cells (ADSCs) from younger and older donors, with an equal number of samples from men and women. These samples underwent RNA sequencing and label-free

SUBMITTER: Feehan J 

PROVIDER: S-EPMC11369222 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature