Toward decoding spatiotemporal signaling activities of reactive immunometabolites with precision immuno-chemical biology tools.

ABSTRACT: Immune-cell reprogramming driven by mitochondria-derived reactive electrophilic immunometabolites (mt-REMs-e.g., fumarate, itaconate) is an emerging phenomenon of major biomedical importance. Despite their localized production, mt-REMs elicit significantly large local and global footprints within and across cells, through mechanisms involving electrophile signaling. Burgeoning efforts are being put into profiling mt-REMs' potential protein-targets and phenotypic mapping of their multifaceted inflammatory behaviors. Yet, precision indexing of mt-REMs' first-responders with spatiotemporal intelligence and locale-specific function assignments remain elusive. Highlighting the latest advances and overarching challenges, this perspective aims to stimulate thoughts and spur interdisciplinary inno

SUBMITTER: Huang KT 

PROVIDER: S-EPMC11369232 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature