A Boolean model explains phenotypic plasticity changes underlying hepatic cancer stem cells emergence.

ABSTRACT: In several carcinomas, including hepatocellular carcinoma, it has been demonstrated that cancer stem cells (CSCs) have enhanced invasiveness and therapy resistance compared to differentiated cancer cells. Mathematical-computational tools could be valuable for integrating experimental results and understanding the phenotypic plasticity mechanisms for CSCs emergence. Based on the literature review, we constructed a Boolean model that recovers eight stable states (attractors) corresponding to the gene expression profile of hepatocytes and mesenchymal cells in senescent, quiescent, proliferative, and stem-like states. The epigenetic landscape associated with the regulatory network was analyzed. We observed that the loss of p53, p16, RB, or the constitutive activation of β-catenin and YAP1 incr

SUBMITTER: Hernandez-Magana A 

PROVIDER: S-EPMC11369243 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature