Vitamin B12 status and skeletal muscle function among elderly: A literature review and pilot study on the effect of oral vitamin B12 supplementation in improving muscle function.

ABSTRACT:

Objectives

The objective of this study is to understand the role of vitamin B12 supplementation in improving skeletal muscle function among the elderly.

Methods

A literature review in the Medline database was conducted to understand the association between vitamin B12 and muscle function in Section A. In Section B, 28 healthy elderly participants aged ≥60 years were recruited in a cross-sectional design for estimation of plasma vitamin B12 status and assessment of upper limb muscle strength Maximal voluntary contraction (MVC) and muscle quality (expressed as MVC/total muscle mass). Participants were grouped based on vitamin B12 status into vitamin B12-depleted (<148 pmol/L) and replete (≥148 pmol/L) groups. In a quasi-experimental study design, the vitamin B12-depleted group

SUBMITTER: Sharma S 

PROVIDER: S-EPMC11369341 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature