Intracellular peroxynitrite perturbs redox balance, bioenergetics, and Fe-S cluster homeostasis in Mycobacterium tuberculosis.

ABSTRACT: The ability of Mycobacterium tuberculosis (Mtb) to tolerate nitric oxide (^•NO) and superoxide (O₂^•-) produced by phagocytes contributes to its success as a human pathogen. Recombination of ^•NO and O₂^•- generates peroxynitrite (ONOO^-), a potent oxidant produced inside activated macrophages causing lethality in diverse organisms. While the response of Mtb toward ^•NO and O₂^•- is well established, how Mtb responds to ONOO^- remains unclear. Filling this knowledge gap is important to understand the persistence mechanisms of Mtb during infection. We synthesized a series of compounds that generate both ^•NO and O₂^•-, which should combine to produc

SUBMITTER: Dewan A 

PROVIDER: S-EPMC11369450 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature