PTOV1 facilitates colorectal cancer cell proliferation through activating AKT1 signaling pathway.

ABSTRACT:

Background

Colorectal cancer is a predominant contributor to global cancer-related morbidity and mortality. The oncogene PTOV1 has been linked to various human malignancies, yet its specific role in CRC pathogenesis requires further elucidation.

Methods

Our study used a comprehensive array of authoritative bioinformatics tools, such as TIMER, UCSC Xena, GEO, Human Protein Atlas, UALCAN, CIBERSORTx and others which used to investigate the complex effects of PTOV1 on gene expression profiles, diagnostic and prognostic biomarkers, tumor immunology, signaling pathways, epigenetic alterations, and genetic mutations. Gene expression validation was conducted using Western blot and qRT-PCR. The in vitro proliferative and migratory potentials of CRC cells were evaluated using CCK-8 a

SUBMITTER: Xie SA 

PROVIDER: S-EPMC11369455 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature