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Novel perspectives on leptin in osteoarthritis: Focus on aging.

ABSTRACT: Osteoarthritis (OA) is a common chronic joint disease characterized by articular cartilage degeneration, subchondral sclerosis, synovitis, and osteophyte formation. OA is associated with disability and impaired quality of life, particularly among the elderly. Leptin, a 16-kD non-glycosylated protein encoded by the obese gene, is produced on a systemic and local basis in adipose tissue and the infrapatellar fat pad located in the knee. The metabolic mechanisms employed by leptin in OA development have been widely studied, with attention being paid to aging as a corroborative risk factor for OA. Hence, in this review, we have attempted to establish a potential link between leptin and OA, by focusing on aging-associated mechanisms and proposing leptin as a potential diagnostic and therapeutic target in aging-related mechanisms of OA that may provide fruitful guidance and emphasis for future research.

SUBMITTER: Liu Z

PROVIDER: S-EPMC11369483 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature

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Novel perspectives on leptin in osteoarthritis: Focus on aging.

Liu Zimo Z Xie Wenqing W Li Hengzhen H Liu Xu X Lu Yao Y Lu Bangbao B Deng Zhenhan Z Li Yusheng Y

Genes & diseases 20231104 6

Osteoarthritis (OA) is a common chronic joint disease characterized by articular cartilage degeneration, subchondral sclerosis, synovitis, and osteophyte formation. OA is associated with disability and impaired quality of life, particularly among the elderly. Leptin, a 16-kD non-glycosylated protein encoded by the obese gene, is produced on a systemic and local basis in adipose tissue and the infrapatellar fat pad located in the knee. The metabolic mechanisms employed by leptin in OA development ...[more]

PMID: 39229323

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