The role of inflammatory proteins in regulating the impact of lipid specifications on deep venous thrombosis: a two sample and mediated Mendelian randomization study.

ABSTRACT:

Objective

To investigate the potential mediating role of inflammatory proteins in the association between lipid species and Deep Venous Thrombosis (DVT).

Methods

A comprehensive analysis was conducted using pooled data from genome-wide association studies (GWAS), incorporating double-sample and reverse Mendelian randomization (MR) techniques, to identify the specific inflammatory proteins that act as intermediaries among 91 screened proteins in relation to deep vein thrombosis (DVT). Furthermore, a two-step MR approach was employed to quantify the proportion of DVT risk attributed to lipid effects mediated by these inflammatory proteins.

Results

The MR Analysis revealed that the two inflammatory proteins, as predicted by genetics, served as mediating factors in the im

SUBMITTER: Dong F 

PROVIDER: S-EPMC11369674 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature