Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer.

ABSTRACT: Activation in transformed cells of normal stem cells' self-renewal pathways might contribute to the survival life cycle of cancer stem cells and promote tumor progression. The BMI-1 oncogene-driven gene expression pathway is essential for the self-renewal of hematopoietic and neural stem cells. We applied a mouse/human comparative translational genomics approach to identify an 11-gene signature that consistently displays a stem cell-resembling expression profile in distant metastatic lesions as revealed by the analysis of metastases and primary tumors from a transgenic mouse model of prostate cancer and cancer patients. To further validate these results, we examined the prognostic power of the 11-gene signature in several independent therapy-outcome sets of clinical samples obtained from 1

SUBMITTER: Glinsky GV 

PROVIDER: S-EPMC1136989 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature