Minimum spanning tree analysis of unimpaired individuals at risk of Alzheimer's disease.

ABSTRACT: Identifying early and non-invasive biomarkers to detect individuals in the earliest stages of the Alzheimer's disease continuum is crucial. As a result, electrophysiology and plasma biomarkers are emerging as great candidates in this pursuit due to their low invasiveness. This is the first magnetoencephalography study to assess the relationship between minimum spanning tree parameters, an alternative to overcome the comparability and thresholding problem issues characteristic of conventional brain network analyses, and plasma phosphorylated tau231 levels in unimpaired individuals, with different risk levels of Alzheimer's disease. Seventy-six individuals with available magnetoencephalography recordings and phosphorylated tau231 plasma determination were included. The minimum spanning tree

SUBMITTER: Garcia-Colomo A 

PROVIDER: S-EPMC11369931 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature