Efficacy and safety of pharmacotherapy for cancer cachexia: A systematic review and network meta-analysis.

ABSTRACT:

Background

Cancer cachexia affects more than half of all cancer patients, reducing survival rates. Evidence-based approaches are urgently needed to optimize treatment.

Methods

A systematic review and network meta-analysis were conducted to assess the effectiveness and safety of different pharmacotherapies for cancer cachexia. Three databases (PubMed, Cochrane Library, and Web of Science) were searched for the period from January 1, 2000, to March 20, 2024. The netmeta package in R software was used to calculate the pooled effect, employing a random effects model.

Results

Seven placebo-controlled randomized trials involving 1421 patients were analyzed. Pairwise analysis showed that body weight increases were 4.6 kg (95% confidence interval [CI] 0.83-8.37 kg) for olanza

SUBMITTER: Chen H 

PROVIDER: S-EPMC11369987 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature