Cleavage and polyadenylation factors are potential regulators of adipogenesis.

ABSTRACT:

Objective

Alternative polyadenylation (APA) is a co-transcriptional process that leads to isoform diversity in the 3' ends of mRNAs. APA is known to occur during differentiation, and its dysregulation is observed in diseases like cancer and autoimmune disorders. It has been previously reported that differentiation of 3T3-L1 cells to adipocytes leads to an overall lengthening of mRNAs, but the proteins involved in this regulation have not been identified. The expression levels of subunits of the cleavage and polyadenylation (C/P) complex can regulate the choice of poly(A) site, which in turn can affect different cellular activities. In this paper, we studied the change in levels of C/P proteins during 3T3-L1 differentiation.

Results

We observed that while the RNA expression o

SUBMITTER: Mostafa SM 

PROVIDER: S-EPMC11370009 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature