Enhanced motor noise in an autism subtype with poor motor skills.

ABSTRACT:

Background

Motor difficulties are common in many, but not all, autistic individuals. These difficulties can co-occur with other problems, such as delays in language, intellectual, and adaptive functioning. Biological mechanisms underpinning such difficulties are less well understood. Poor motor skills tend to be more common in individuals carrying highly penetrant rare genetic mutations. Such mechanisms may have downstream consequences of altering neurophysiological excitation-inhibition balance and lead to enhanced behavioral motor noise.

Methods

This study combined publicly available and in-house datasets of autistic (n = 156), typically-developing (TD, n = 149), and developmental coordination disorder (DCD, n = 23) children (age 3-16 years). Autism motor subtypes were ide

SUBMITTER: Mandelli V 

PROVIDER: S-EPMC11370061 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature