Causal relationship between varicose veins and mean corpuscular hemoglobin concentration based on Mendelian randomization study.

ABSTRACT:

Background

Increased hemoglobin concentrations may increase the risk of varicose veins. However, the underlying relationship between them was not yet understood.

Methods

Mendelian randomization (MR) analysis was performed to investigate causal effect between mean corpuscular hemoglobin concentration (MCHC, exposure factor) and varicose veins (outcome). Afterward, sensitivity analysis was used to ensure the reliability of MR analysis results. Then Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of SNPs were performed. A search tool for recurring instances of neighbouring genes (STRING) database was used to construct a protein-protein interaction (PPI) network.

Results

Therefore, the inverse-variance weighted (IVW) results showe

SUBMITTER: Chen S 

PROVIDER: S-EPMC11370081 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature