Mitotic activity: A systematic literature review of the assessment methodology and prognostic value in feline tumors.

ABSTRACT: Increased proliferation is a driver of tumorigenesis, and quantification of mitotic activity is a standard task for prognostication. This systematic review is an analysis of all available references on mitotic activity in feline tumors to provide an overview of the assessment methods and prognostic value. A systematic literature search in PubMed and Scopus and a nonsystematic search in Google Scholar were conducted. All articles on feline tumors that correlated mitotic activity with patient outcome were identified. Data analysis revealed that of the 42 eligible articles, mitotic count (MC, mitotic figures/tumor area) was evaluated in 39 studies, and mitotic index (MI, mitotic figures/tumor cells) in 3 studies. The risk of bias was considered high for most studies (26/42, 62%) based on smal

SUBMITTER: Bertram CA 

PROVIDER: S-EPMC11370206 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature