SmithHunter: a workflow for the identification of candidate smithRNAs and their targets.

ABSTRACT:

Background

SmithRNAs (Small MITochondrial Highly-transcribed RNAs) are a novel class of small RNA molecules that are encoded in the mitochondrial genome and regulate the expression of nuclear transcripts. Initial evidence for their existence came from the Manila clam Ruditapes philippinarum, where they have been described and whose activity has been biologically validated through RNA injection experiments. Current evidence on the existence of these RNAs in other species is based only on small RNA sequencing. As a preliminary step to characterize smithRNAs across different metazoan lineages, a dedicated, unified, analytical workflow is needed.

Results

We propose a novel workflow specifically designed for smithRNAs. Sequence data (from small RNA sequencing) uniquely mapping to

SUBMITTER: Marturano G 

PROVIDER: S-EPMC11370224 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature