Multilocus sequence typing database for Streptococcus agalactiae contains a spurious allele of the transketolase gene.

ABSTRACT: The tkt (transketolase) gene is one of the seven gene fragments used in the multilocus sequence typing (MLST) system for Streptococcus agalactiae. We discovered that the tkt_134 allele is derived from a homologous gene (which we designate tktX) that is not present in all S. agalactiae; all known strains that contain a match to the tkt_134 allele also contain a gene sequence that is much closer in sequence identity to the other non-tkt_134 alleles (i.e., the canonical tkt gene) in the database. Based on these data, the tkt_134 allele has been removed from the MLST database as of September 2021, and all sequence types containing tkt_134 have also been removed.IMPORTANCEMultilocus sequence typing (MLST) databases are a common good and remain important for research,

SUBMITTER: Chen SL 

PROVIDER: S-EPMC11370237 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature