Epigenetic effects induced by silver nanoparticles in Caenorhabditis elegans after multigenerational exposure.

ABSTRACT: Multigenerational effects of silver nanoparticles (Ag-NPs) on reproduction of the soil nematode Caenorhabditis elegans have been observed previously. However, mechanisms of this reproductive sensitivity are unknown. Here we examine whether epigenetic changes occur as a result of multigenerational exposure to Ag-NPs and whether such modifications can be inherited by unexposed generations. Changes at histone methylation markers, histone 3 lysine 4 dimethylation (H3K4me2) and histone 3 lysine 9 trimethylation (H3K9me3), known to affect reproduction, as well as changes in the expression of the genes encoding demethylases and methyltransferases associated with the selected markers, were investigated. We exposed C. elegans at EC₃₀ to AgNO₃, pristine Ag-NPs, and its environm

SUBMITTER: Wamucho A 

PROVIDER: S-EPMC11370278 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature