Tilorone mitigates the propagation of α-synucleinopathy in a midbrain-like organoid model.

ABSTRACT:

Background

Parkinson's disease (PD) is a neurodegenerative condition characterized by the loss of dopaminergic neurons and the accumulation of Lewy-body protein aggregates containing misfolded α-synuclein (α-syn) in a phosphorylated form. The lack of effective models for drug screens has hindered drug development studies for PD. However, the recent development of in vitro brain-like organoids provides a new opportunity for evaluating therapeutic agents to slow the progression of this chronic disease.

Methods

In this study, we used a 3D brain-like organoid model to investigate the potential of repurposing Tilorone, an anti-viral drug, for impeding the propagation of α-synucleinopathy. We assessed the effect of Tilorone on the uptake of fluorescently labeled α-syn preformed fi

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC11370279 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature