Simulated weightlessness procedure, head-down bed rest has reversible effects on the metabolism of rhesus macaque.

ABSTRACT: It is a consensus in the international manned space field that factors such as microgravity during the space flight can cause anxiety, depression and other important brain function abnormalities in astronauts. However, the neural mechanism at the molecular level is still unclear. Due to the limitations of research conditions, studies of biological changes in the primate brain have been comparatively few. We took advantage of -6° head-down bed rest (HDBR), one of the most implemented space analogues on the ground, to investigate the effects of simulated weightlessness on non-human primate brain metabolites. The Rhesus Macaque monkeys in the experiment were divided into three groups: the control group, the 42-day simulated weightlessness group with HDBR, and the recovery group, which had 28

SUBMITTER: Li Y 

PROVIDER: S-EPMC11370317 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature