Dissecting contributions of pulmonary arterial remodeling to right ventricular afterload in pulmonary hypertension.

ABSTRACT: Pulmonary hypertension (PH) is defined as an elevation in the right ventricle (RV) afterload, characterized by increased hemodynamic pressure in the main pulmonary artery (PA). Elevations in RV afterload increase RV wall stress, resulting in RV remodeling and potentially RV failure. From a biomechanical standpoint, the primary drivers for RV afterload elevations include increases in pulmonary vascular resistance (PVR) in the distal vasculature and decreases in vessel compliance in the proximal PA. However, the individual contributions of the various vascular remodeling events toward the progression of PA pressure elevations and altered vascular hemodynamics remain elusive. In this study, we used a subject-specific one-dimensional (1D) fluid-structure interaction (FSI) model to investigate

SUBMITTER: Neelakantan S 

PROVIDER: S-EPMC11370336 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature