<i>Pseudomonas aeruginosa</i> population dynamics in a vancomycin-induced murine model of gastrointestinal carriage.

ABSTRACT: Pseudomonas aeruginosa is a common nosocomial pathogen and a major cause of morbidity and mortality in hospitalized patients. Multiple reports highlight that P. aeruginosa gastrointestinal colonization may precede systemic infections by this pathogen. Gaining a deeper insight into the dynamics of P. aeruginosa gastrointestinal carriage is an essential step in managing gastrointestinal colonization and could contribute to preventing bacterial transmission and progression to systemic infection. Here, we present a clinically relevant mouse model relying on parenteral vancomycin pretreatment and a single orogastric gavage of a controlled dose of P. aeruginosa. Robust carriage was observed with multiple clinical isolates, and carriage persisted for up to 60 days. His

SUBMITTER: Lebrun-Corbin M 

PROVIDER: S-EPMC11370369 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature