Malnutrition drives infection susceptibility and dysregulated myelopoiesis that persists after refeeding intervention.

ABSTRACT: Undernutrition is one of the largest persistent global health crises, with nearly 1 billion people facing severe food insecurity. Infectious disease represents the main underlying cause of morbidity and mortality for malnourished individuals, with infection during malnutrition representing the leading cause of childhood mortality worldwide. In the face of this complex challenge, simple refeeding protocols have remained the primary treatment strategy. Although an association between undernutrition and infection susceptibility has been appreciated for over a century, the underlying mechanisms remain poorly understood and the extent to which refeeding intervention is sufficient to reverse nutritionally acquired immunodeficiency is unclear. Here we investigate how malnutrition leads to immune

SUBMITTER: Sukhina A 

PROVIDER: S-EPMC11370435 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature