The Clonal Hematopoiesis-associated Gene <i>Srcap</i> Plays an Essential Role in Hematopoiesis.

ABSTRACT: Somatic mutations arising in hematopoietic stem cells (HSCs) may provide the latter with a fitness advantage, allowing the mutant HSC to clonally expand. Such mutations have been recurrently identified in the chromatin modifier, SRCAP, in both non-malignant and leukemic clones, suggesting that this gene plays a significant role in hematopoiesis. We generated a conditional Srcap loss of function murine model and determined the consequences of hematopoietic-specific loss of this gene. We show that Srcap is essential for normal fetal liver erythropoiesis and monocytopoiesis. In Srcap deficient fetal livers, the number of phenotypic HSCs is similar to that of controls, but these HSCs exhibit a profound repopulating defect. Likewise, conditional deletion of Srcap<

SUBMITTER: Wong TN 

PROVIDER: S-EPMC11370474 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature