Altered neurobehavioral reward response predicts psychotic-like experiences in youth exposed to cannabis prenatally.

ABSTRACT:

Importance

Rates of prenatal cannabis exposure (PCE) are rising with increasingly permissive legislation regarding cannabis use, which may be a risk factor for psychosis. Disrupted reward-related neural circuitry may underlie this relationship.

Objective

To elucidate neural mechanisms involved in the association between PCE and youth-onset psychotic-like experiences by probing correlates of reward anticipation, a neurobehavioral marker of endocannabinoid-mediated dopaminergic function.

Design setting and participants

This longitudinal, prospective study analyzed task-related functional neuroimaging data from baseline (n=11,368), 2-year follow-up (n=7,928), and 4-year follow-up (n=2,982) of the ongoing Adolescent Brain and Cognitive Development (ABCD) Study, which recr

SUBMITTER: Amir CM 

PROVIDER: S-EPMC11370518 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature