Identifying novel chemical matter against the Chikungunya virus nsP3 macrodomain through crystallographic fragment screening.

ABSTRACT: Chikungunya virus (CHIKV) causes severe fever, rash and debilitating joint pain that can last for months^1,2or even years. Millions of people have been infected with CHIKV, mostly in low and middle-income countries, and the virus continues to spread into new areas due to the geographical expansion of its mosquito hosts. Its genome encodes a macrodomain, which functions as an ADP-ribosyl hydrolase, removing ADPr from viral and host-cell proteins interfering with the innate immune response. Mutational studies have shown that the CHIKV nsP3 macrodomain is necessary for viral replication, making it a potential target for the development of antiviral therapeutics. We, therefore, performed a high-throughput crystallographic fragment screen against the CHIKV nsP3 macrodomain, yielding 1

SUBMITTER: Aschenbrenner JC 

PROVIDER: S-EPMC11370605 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature