<i>Girk3</i> deletion increases osteoblast maturation and bone mass accrual in adult male mice.

ABSTRACT: Osteoporosis and other metabolic bone diseases are prevalent in the aging population. While bone has the capacity to regenerate throughout life, bone formation rates decline with age and contribute to reduced bone density and strength. Identifying mechanisms and pathways that increase bone accrual in adults could prevent fractures and accelerate healing. G protein-gated inwardly rectifying K⁺ (GIRK) channels are key effectors of G protein-coupled receptor signaling. Girk3 was recently shown to regulate endochondral ossification. Here, we demonstrate that deletion of Girk3 increases bone mass after 18 weeks of age. Male 24-week-old Girk3 ^-/- mice have greater trabecular bone mineral density and bone volume fraction than wildtype (WT) mice. Osteobla

SUBMITTER: Weaver SR 

PROVIDER: S-EPMC11370632 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature