Analysis and identification of ferroptosis-related diagnostic markers in rheumatoid arthritis.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is an autoimmune, inflammatory joint disease. There is growing evidence that ferroptosis is involved in the pathogenesis of RA. This study aimed to search for diagnostic markers of ferroptosis in RA and to analyse the potential mechanisms and clinical value.

Materials and methods

RA-associated datasets were used from the publicly available GEO database. Three methods of machine learning were applied to screen biomarkers. The diagnostic efficacy of the results was also verified by receiver operating characteristic (ROC) curve, external dataset, qRT-PCR and Western blot. Enrichment analysis was performed in this process, while protein-protein interaction (PPI) analysis and immune infiltration correlation analysis were performed using biomar

SUBMITTER: Cai Y 

PROVIDER: S-EPMC11370691 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature