Efficacy and safety of biologics, multitarget therapy, and standard therapy for lupus nephritis: a systematic review and network meta-analysis.

ABSTRACT:

Objective

This study aimed to compare the efficacy and safety of biologics, multitarget therapy, and standard therapy for the induction of lupus nephritis.

Methods

A systematic search of electronic databases (EMBASE, Web of Science, PubMed, Cochrane Library, and ClinicalTrials.gov) was conducted from inception to 30 August 2023. Our study included randomized controlled trials enrolling adult lupus nephritis patients treated with biologics or multitarget therapy, in comparison with standard therapy. The primary outcomes were the rates of complete renal remission (CRR) and serious adverse events (SAE). Stata 15.0 was used to conduct the network meta-analysis.

Results

Ten randomized controlled trials with a total of 1989 patients met the inclusion criteria. The network m

SUBMITTER: Tian GQ 

PROVIDER: S-EPMC11370699 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature