The interictal suppression hypothesis is the dominant differentiator of seizure onset zones in focal epilepsy.

ABSTRACT: Successful surgical treatment of drug-resistant epilepsy traditionally relies on the identification of seizure onset zones (SOZs). Connectome-based analyses of electrographic data from stereo electroencephalography (SEEG) may empower improved detection of SOZs. Specifically, connectome-based analyses based on the interictal suppression hypothesis posit that when the patient is not having a seizure, SOZs are inhibited by non-SOZs through high inward connectivity and low outward connectivity. However, it is not clear whether there are other motifs that can better identify potential SOZs. Thus, we sought to use unsupervised machine learning to identify network motifs that elucidate SOZs and investigate if there is another motif that outperforms the ISH. Resting-state SEEG data from 81 patient

SUBMITTER: Doss DJ 

PROVIDER: S-EPMC11370787 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature