Distinctive antibody responses to Mycobacterium tuberculosis in pulmonary and brain infection.

ABSTRACT: Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), remains a global health burden. While M. tuberculosis is primarily a respiratory pathogen, it can spread to other organs, including the brain and meninges, causing TB meningitis (TBM). However, little is known about the immunological mechanisms that lead to differential disease across organs. Attention has focused on differences in T cell responses in the control of M. tuberculosis in the lungs, but emerging data point to a role for antibodies, as both biomarkers of disease control and as antimicrobial molecules. Given an increasing appreciation for compartmentalized antibody responses across the blood-brain barrier, here we characterized the antibody profiles across the blood and brain compartments in TBM and determined

SUBMITTER: Spatola M 

PROVIDER: S-EPMC11370789 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature