Shared patterns of glial transcriptional dysregulation link Huntington's disease and schizophrenia.

ABSTRACT: Huntington's disease and juvenile-onset schizophrenia have long been regarded as distinct disorders. However, both manifest cell-intrinsic abnormalities in glial differentiation, with resultant astrocytic dysfunction and hypomyelination. To assess whether a common mechanism might underlie the similar glial pathology of these otherwise disparate conditions, we used comparative correlation network approaches to analyse RNA-sequencing data from human glial progenitor cells (hGPCs) produced from disease-derived pluripotent stem cells. We identified gene sets preserved between Huntington's disease and schizophrenia hGPCs yet distinct from normal controls that included 174 highly connected genes in the shared disease-associated network, focusing on genes involved in synaptic signalling. These sy

SUBMITTER: Huynh NPT 

PROVIDER: S-EPMC11370805 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature