Toxicity by descent: A comparative approach for chemical hazard assessment.

ABSTRACT: Toxicology is traditionally divided between human and eco-toxicology. In the shared pursuit of environmental health, this separation does not account for discoveries made in the comparative studies of animal genomes. Here, we provide evidence on the feasibility of understanding the health impact of chemicals on all animals, including ecological keystone species and humans, based on a significant number of conserved genes and their functional associations to health-related outcomes across much of animal diversity. We test four conditions to understand the value of comparative genomics data to inform mechanism-based human and environmental hazard assessment: (1) genes that are most fundamental for health evolved early during animal evolution; (2) the molecular functions of path

SUBMITTER: Colbourne JK 

PROVIDER: S-EPMC11370884 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature