Immunomethylomic profiles of long-term head and neck squamous cell carcinoma survivors on immune checkpoint inhibitors.
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ABSTRACT:
SUBMITTER: Lee MK
PROVIDER: S-EPMC11370916 | biostudies-literature | 2024
REPOSITORIES: biostudies-literature
Publications
Immunomethylomic profiles of long-term head and neck squamous cell carcinoma survivors on immune checkpoint inhibitors.
Lee Min Kyung MK Zhang Ze Z Sehgal Kartik K Butler Rondi R Stolrow Hannah H Ramush Geat G Shirai Keisuke K Koestler Devin C DC Salas Lucas A LA Wiencke John K JK Haddad Robert R Kelsey Karl T KT Christensen Brock C BC
Epigenomics 20240517 11-12
<b>Aim:</b> This study addresses the challenge of predicting the response of head and neck squamous cell carcinoma (HNSCC) patients to immunotherapy.<b>Methods:</b> Using DNA methylation cytometry, we analyzed the immune profiles of six HNSCC patients who showed a positive response to immunotherapy over a year without disease progression.<b>Results:</b> There was an initial increase in CD8 T memory cells and natural killer cells during the first four cycles of immunotherapy, which then returned ...[more]
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