Identification of novel benzothiazole-thiadiazole-based thiazolidinone derivative: <i>in vitro</i> and <i>in silico</i> approaches to develop promising anti-Alzheimer's agents.

ABSTRACT: Aim: The present study describes benzothiazole derived thiazolidinone based thiadiazole derivatives (1-16) as anti-Alzheimer agents.Materials & methods: Synthesis of benzothiazole derived thiazolidinone based thiadiazole derivatives was achieved using the benzothiazole bearing 2-amine moiety. These synthesized compounds were confirmed via spectroscopic techniques (¹H NMR, ¹³C NMR and HREI-MS). These compounds were biologically evaluated for their anti-Alzheimer potential. Binding interactions with proteins and drug likeness of the analogs were explored through molecular docking and ADMET analysis, respectively. In the novel series, compound-3 emerged as the most potent inhibitor when compared with other derivatives of the series.Conclusi

SUBMITTER: Khan S 

PROVIDER: S-EPMC11370920 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature