Simulating the clinical manifestations and disease progression of human sepsis: A monobacterial injection approach for animal modeling.

ABSTRACT: Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, with great clinical heterogeneity, high morbidity, and high mortality. At the same time, there are many kinds of infection sources, the pathophysiology is very complex, and the pathogenesis has not been fully elucidated. An ideal animal model of sepsis can accurately simulate clinical sepsis and promote the development of sepsis-related pathogenesis, treatment methods, and prognosis. The existing sepsis model still uses the previous Sepsis 2.0 modelling standard, which has some problems, such as many kinds of infection sources, poor repeatability, inability to take into account single-factor studies, and large differences from clinical sepsis patients. To solve these problems, this

SUBMITTER: Ru X 

PROVIDER: S-EPMC11370922 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature