Alpha-boswellic acid accelerates acute wound healing via NF-κB signaling pathway.

ABSTRACT:

Background

Boswellic acids (BAs) showed promising effects in cancer treatment, immune response regulation, and anti-inflammatory therapy. We aimed to assess the roles of alpha-BA (α-BA) in treating acute wound healing.

Methods

In vivo wound-healing models were established to evaluate the therapeutic effects of α-BA. Cell assays were conducted to assess the impact of α-BA on cellular biological functions. Western blot analysis was employed to validate the potential mechanisms of action of α-BA.

Results

Animal models indicated that wound healing was notably accelerated in the α-BA group compared to the control group (P < 0.01). Hematoxylin and eosin (HE) staining and enzyme-linked immunosorbent assay (ELISA) assay preliminarily suggested that α-BA may accelerate wound h

SUBMITTER: Dong F 

PROVIDER: S-EPMC11371135 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature