Dataset Information

Association of Carotid Intima Media Thickening with Future Brain Region Specific Amyloid-β Burden.

ABSTRACT:

Background

Carotid atherosclerosis is associated with cognitive impairment and dementia, though there is limited evidence of a direct link between carotid disease and amyloid-β (Aβ) burden.

Objective

We studied the association of baseline and progressive carotid intima media thickness (CIMT) with Aβ on 11C-Pittsburgh Compound B (PiB) to determine if those with carotid atherosclerosis would have higher Aβ burden.

Methods

We studied 47 participants from the Framingham Offspring cohort with carotid ultrasounds measuring CIMT at their 6th clinic examination (aged 49.5±5.7 years) and an average of 9.6 years later, and PiB imaging measuring Aβ on average 22.1 years post baseline. We used multivariate linear regression analyses to relate baseline, follow-up, mean, and progression of internal carotid artery (ICA) and common carotid artery (CCA) CIMT to Aβ in brain regions associated with Alzheimer's disease (AD) and related dementias (ADRD), adjusting for age, sex, and other vascular risk factors.

Results

Participants with higher mean ICA IMT had more Aβ in the precuneus (beta±standard error [β±SE]: 0.466±0.171 mm, p = 0.01) and the frontal, lateral, and retrosplenial regions (β±SE: 0.392±0.164 mm, p = 0.022) after adjusting for age, sex, vascular risk factors, and medication use. We did not find an association between any CCA IMT measures and Aβ or progression of ICA or CCA IMT and Aβ.

Conclusion

Carotid atherosclerosis, as measured by ICA IMT, is associated with increased Aβ burden later in life. These findings support a link between vascular disease and AD/ADRD pathophysiology.

SUBMITTER: Baradaran H

PROVIDER: S-EPMC11371395 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Association of Carotid Intima Media Thickening with Future Brain Region Specific Amyloid-β Burden.

Baradaran Hediyeh H Peloso Gina M GM Polak Joseph F JF Killiany Ronald J RJ Ghosh Saptaparni S DeCarli Charles S CS Thibault Emma G EG Sperling Reisa A RA Johnson Keith A KA Beiser Alexa A Romero Jose R JR Seshadri Sudha S

Journal of Alzheimer's disease : JAD 20220101 1

<h4>Background</h4>Carotid atherosclerosis is associated with cognitive impairment and dementia, though there is limited evidence of a direct link between carotid disease and amyloid-β (Aβ) burden.<h4>Objective</h4>We studied the association of baseline and progressive carotid intima media thickness (CIMT) with Aβ on 11C-Pittsburgh Compound B (PiB) to determine if those with carotid atherosclerosis would have higher Aβ burden.<h4>Methods</h4>We studied 47 participants from the Framingham Offspri ...[more]

PMID: 35871328

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Dataset Information

Association of Carotid Intima Media Thickening with Future Brain Region Specific Amyloid-β Burden.

Background

Objective

Methods

Results

Conclusion

Publications

Association of Carotid Intima Media Thickening with Future Brain Region Specific Amyloid-β Burden.

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