P21-activated kinase-1 signaling is required to preserve adipose tissue homeostasis and cardiac function.

ABSTRACT: While P21-activated kinase-1 (PAK1) has been extensively studied in relation to cardiovascular health and glucose metabolism, its roles within adipose tissue and cardiometabolic diseases are less understood. In this study, we explored the effects of PAK1 deletion on energy balance, adipose tissue homeostasis, and cardiac function utilizing a whole-body PAK1 knockout (PAK1^-/-) mouse model. Our findings revealed that body weight differences between PAK1^-/- and WT mice emerged at 9 weeks of age, with further increases observed at 12 weeks. Furthermore, PAK1^-/- mice displayed increased fat mass and decreased lean mass at 12 weeks, indicating a shift towards adiposity. In conjunction with the increased body weight, PAK1^-/- mice had increased food inta

SUBMITTER: Munoz M 

PROVIDER: S-EPMC11371416 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature