Transcriptional and morphological responses following distinct muscle contraction protocols for Snell dwarf (Pit1^dw/dw) mice.

ABSTRACT: The Snell dwarf mouse (Pit1^dw/dw), an animal model of congenital combined pituitary hormone deficiency, displays skeletal muscle weakness. While enhanced responsivity to repeated exposures of muscle contractions have been documented for Snell dwarf mice, the response following single exposure to distinct contraction protocols remained uncharacterized. The purpose of this study was to investigate the muscle recovery of Snell dwarf and control littermate mice following a single exposure to two separate protocols-an intermittent slow velocity (30°/s) contraction protocol or a continuous rapid velocity (500°/s) contraction protocol. Following both protocols for control mice, torque values were 30% and 80% of pre-protocol values at 5 min and 3 days, respectively. At 10 days, performa

SUBMITTER: Rader EP 

PROVIDER: S-EPMC11371489 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature