Sulfated vitamin D metabolites represent prominent roles in serum and in breastmilk of lactating women.

ABSTRACT:

Background

Concentrations of vitamin D (VitD) and 25-hydroxyvitamin D (25OHD) in breastmilk are low despite the essential role of VitD for normal infant bone development, yet additional metabolic forms of vitamin D may be present. This study evaluates the contribution of sulfated vitamin D metabolites, vitamin D₃-sulfate (VitD₃-S) and 25-hydroxyvitamin D₃-sulfate (25OHD₃-S) for lactating women and assesses the response to high-dose VitD₃ supplementation.

Methods

Serum and breastmilk were measured before and after 28 days with 5000 IU/day VitD₃ intake in 20 lactating women. Concentrations of VitD₃-S and 25OHD₃-S in milk, and 25OHD₂, 25OHD₃, 25OHD₃-S, VitD

SUBMITTER: Reynolds CJ 

PROVIDER: S-EPMC11371494 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature