Deciphering the causal association and underlying transcriptional mechanisms between telomere length and abdominal aortic aneurysm.

ABSTRACT:

Background

The purpose of this study is to investigate the causal effect and potential mechanisms between telomere length and abdominal aortic aneurysm (AAA).

Methods

Summary statistics of telomere length and AAA were derived from IEU open genome-wide association studies and FinnGen R9, respectively. Bi-directional Mendelian randomization (MR) analysis was conducted to reveal the causal relationship between AAA and telomere length. Three transcriptome datasets were retrieved from the Gene Expression Omnibus database and telomere related genes was down-loaded from TelNet. The overlapping genes of AAA related differentially expressed genes (DEGs), module genes, and telomere related genes were used for further investigation. Telomere related diagnostic biomarkers of AAA were se

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11371612 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature