Neuroglycome alterations of hippocampus and prefrontal cortex of juvenile rats chronically exposed to glyphosate-based herbicide.

ABSTRACT:

Introduction

Glyphosate-based herbicides (GBHs) have been shown to have significant neurotoxic effects, affecting both the structure and function of the brain, and potentially contributing to the development of neurodegenerative disorders. Despite the known importance of glycosylation in disease progression, the glycome profile of systems exposed to GBH has not been thoroughly investigated.

Methods

In this study, we conducted a comprehensive glycomic profiling using LC-MS/MS, on the hippocampus and prefrontal cortex (PFC) of juvenile rats exposed to GBH orally, aiming to identify glyco-signature aberrations after herbicide exposure.

Results

We observed changes in the glycome profile, particularly in fucosylated, high mannose, and sialofucosylated N-glycans, which may

SUBMITTER: Solomon J 

PROVIDER: S-EPMC11371619 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature