Fc-engineered antibodies promote neutrophil-dependent control of Mycobacterium tuberculosis.

ABSTRACT: Mounting evidence indicates that antibodies can contribute towards control of tuberculosis (TB). However, the underlying mechanisms of humoral immune protection and whether antibodies can be exploited in therapeutic strategies to combat TB are relatively understudied. Here we engineered the receptor-binding Fc (fragment crystallizable) region of an antibody recognizing the Mycobacterium tuberculosis (Mtb) capsule, to define antibody Fc-mediated mechanism(s) of Mtb restriction. We generated 52 Fc variants that either promote or inhibit specific antibody effector functions, rationally building antibodies with enhanced capacity to promote Mtb restriction in a human whole-blood model of infection. While there is likely no singular Fc profile that universally drives control of Mtb, here we foun

SUBMITTER: Irvine EB 

PROVIDER: S-EPMC11371646 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature