Luteolin as potential treatment for Huntington's disease: Insights from a transgenic mouse model.

ABSTRACT:

Aims

The study aimed to evaluate the potential benefits of luteolin treatment in Huntington's disease (HD), an inherited progressive neurodegenerative disorder.

Methods

HD N171-82Q transgenic and WT mice received luteolin or vehicle for treatment at 6 weeks of age. The mice's body weight changes and survival rates were monitored throughout the study, and a series of motor functional tests were conducted. Serum level of the marker NfL was also determined. Immunohistochemical staining and western blotting were utilized to assess the expression of huntingtin aggregates.

Results

Luteolin treatment enhanced survival and prevented weight loss in HD mice compared to the vehicle-treated HD group. Furthermore, the luteolin-treated HD mice exhibited enhanced motor coordination

SUBMITTER: Mohammed A 

PROVIDER: S-EPMC11371662 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature