Genetic polymorphisms and platinum-induced hematological toxicity: a systematic review.

ABSTRACT:

Background

Platinum-based chemotherapy bring severe hematological toxicity that can lead to dose reduction or discontinuation of therapy. Genetic variations have been reported to influence the risk and extent of hematological toxicity; however, the results are controversial and a comprehensive overview is lacking. This systematic review aimed to identify genetic biomarkers of platinum-induced hematological toxicity.

Method

Pubmed, Embase and Web of science database were systematically reviewed for studies that evaluated the association of genetic variants and platinum-related hematological toxicity in tumor patients with no prior history of chemotherapy or radiation, published from inception to the 28th of January 2022. The studies should have specific toxicity scoring syste

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC11371761 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature