Proteomics analysis of periplaque and chronic inactive multiple sclerosis lesions.

ABSTRACT:

Background

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system characterized by increased inflammation and immune responses, oxidative injury, mitochondrial dysfunction, and iron dyshomeostasis leading to demyelination and axonal damage. In MS, incomplete remyelination results in chronically demyelinated axons and degeneration coinciding with disability. This suggests a failure in the ability to remyelinate in MS, however, the precise underlying mechanisms remain unclear. We aimed to identify proteins whose expression was altered in chronic inactive white matter lesions and periplaque white matter in MS tissue to reveal potential pathophysiological mechanisms.

Methods

Laser capture microdissection coupled to proteomics was used to interrogate spa

SUBMITTER: Wilkins JM 

PROVIDER: S-EPMC11371774 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature